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Role of α-cell Produced Gcg in Insulin Secretion α-Cell GLP-1 during metabolic stress PC1/3, which processes GLP-1 (and GLP-2 and oxyntomodulin) from Gcg , is more predominantly expressed in the gut and CNS, but α-cell PC1/3 activity and/or expression is found in embryonic and neonatal mice, with pregnancy, and in models of prediabetes and diabetes (118, 172, 224, 245)
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